Mortgage loan calculette pret immobilier and the Road to Financial ...

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Individual gene differences can be tested in zebrafish

ScienceDaily (Oct. 25, 2012) ? The zebrafish is a potential tool for testing one class of unique individual genetic differences found in humans, and may yield information helpful for the emerging field of personalized medicine, according to a team led by Penn State College of Medicine scientists. The differences, or mutations, in question create minor changes in amino acids -- the building blocks of DNA -- from person to person. Zebrafish can be used as a model to understand what biological effects result from these genetic mutations.

Personalized medicine uses modern technology and tools to find biological and genetic differences in individuals so that treatment is more effectively delivered.

"A major challenge of personalized medicine is the lack of a standard way to define the importance of each of the many unique mutations found in an individual's genetic code," said Keith Cheng, M.D., Ph.D., professor of pathology and lead researcher. "Approaches are particularly needed to experimentally determine what differences these mutations make. It is difficult to distinguish the effects of a single amino acid change caused by those changes in our DNA."

The zebrafish is a good choice because of its similarity to humans as a vertebrate, its transparency as an embryo and the powerful genetic tools available in this model organism.

The Cheng lab's approach is like testing small damages in car parts, one at a time. For example, a "mutant" car headlight is known not to work when a certain connector is missing. Taking a normally functioning connector out of a working headlight and replacing it with a connector damaged in a specific way -- a cracked wire casing or a corroded wire connector, for example -- can show whether the damage matters. If the light works, then that mutation makes no difference on the function of the headlight. If the light does not work, the mutation has an effect.

Postdoctoral fellow Zurab Tsetskhladze, who performed the zebrafish experiments, tested this method with two genes that affect skin color. He started with an equivalent of the broken car part: mutant zebrafish with lighter pigment cells. First, Tsetskhladze confirmed that by injecting normal messenger RNA (ribonucleic acid) into the mutant zebrafish, the lighter pigment cells become "cured" -- or darker --like those of a normal zebrafish. Messenger RNA makes the cells produce the protein the scientists want to study.

Tsetskhladze was then able to test RNA with only one "human" mutation to see if cure was still possible. Cure suggests that the mutation does not matter. If cure is prevented by the mutation, the conclusion is that the protein's function is affected by the amino acid difference being tested.

Cheng's lab works with zebrafish to study genetic differences that contribute to human skin color. Scientists want to determine the role these differences play in the development of skin cancer, and to find ways to better protect people from cancer.

In the current study, two of the amino acid differences that Cheng has shown in prior studies to contribute to light skin color in humans prevented the zebrafish color from darkening. A third amino acid difference that is common in Eastern Asians was of unknown effect. The researchers found that the change made no difference in function in zebrafish. This finding matched the findings of K.C. Ang, postdoctoral fellow, who found no effect of the tested change on the skin color of East Asians.

To see if this approach might be used in other ways, Stephen Wentzel, graduate student, Penn State College of Medicine, looked at mutations in the four genes known to contribute to albinism, which lightens the color of skin, eyes and hair, and is associated with any one of more than 250 known single amino acid differences. He found that at least 210 of these are theoretically testable in the zebrafish. This new test may help scientists to determine which mutations can be ignored and which may need action -- such as a change in life habit.

"This approach may potentially be extended to other biological functions and may therefore be useful in personalized medicine," Cheng said.

The researchers published their findings in PLoS ONE.

Other researchers are Khai C. Ang, Steven M. Wentzel and Katherine P. Reid, all of Jake Gittlen Cancer Research Foundation, Division of Experimental Pathology, Penn State College of Medicine; Victor A. Canfield, Department of Pharmacology, Penn State College of Medicine; Arthur S. Berg, Department of Public Health Sciences, and Stephen L. Johnson, Department of Genetics, Washington University Medical School; and Koichi Kawakami, Division of Molecular and Developmental Biology, National Institute of Genetics, Japan.

This work was funded by a grant from the National Institutes of Health.

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Story Source:

The above story is reprinted from materials provided by Penn State.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Zurab R. Tsetskhladze, Victor A. Canfield, Khai C. Ang, Steven M. Wentzel, Katherine P. Reid, Arthur S. Berg, Stephen L. Johnson, Koichi Kawakami, Keith C. Cheng. Functional Assessment of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish. PLoS ONE, 2012; 7 (10): e47398 DOI: 10.1371/journal.pone.0047398

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/8YhO4l5p7_0/121025161749.htm

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Hands on Equations (for iPad)

The iTunes App Store is full of educational apps that bring interactive learning to children's fingertips, and Hands on Equations is intended to "demystify" the process of learning algebra. With this iPad ?app, students watch a short video clip explaining a concept before working on practice problems. The Hands on Equations for the iPad is easy to navigate and does the job of teaching algebra, but the app railroads students through the lessons without making the process fun or overly interactive.

Hands on Equations is broken out into three different levels. Level 1 costs $4.99 and offers six different lessons. Both Level 2 and Level 3 offers eight lessons and cost $3.99. I reviewed the "Lite" version of Level 1, which offers the first three Level 1 lessons free of charge. Whenever I was ready to upgrade to the full version of Level 1, or buy any of the other levels, I could click on the relevant buttons right on the main menu.

Each lesson offers a short instructional video and two practice problems, followed by 10 extra exercises. There is no way to jump ahead and just do the problems, because the problems are "locked," and has a little lock icon to show that the student can't access that component yet. Users have to watch the video before the practices are unlocked, and the practice problems have to be completed before the exercises are available.

The Hands on Equation Experience
When the app launches, it displays a main screen which has been designed to look like a lined notebook paper. A video player at the top plays a short clip explaining how to use the app, and each lesson is listed below the player. Buttons to purchase the full version of Level 1, as well as Levels 2 and 3 are on the right side of the screen.

As mentioned earlier, Level 1 Lite displays the video, practice problems, and exercises for only three lessons. When I clicked on the video checkbox on the main screen, I was taken to a different notebook page with a larger video player.

Each lesson's video clip is about three to four minutes long, and explains simple algebraic concepts using a balance scale, dice, and chess pieces. The clips are a little boring, as it shows the instructor pointing to the iPad screen and explaining how to solve the practice problems. Considering this is an iPad app, it would have been better to take advantage of the iPad's interactive capabilities to really create an interactive lesson, instead of making students watch the clip. After the video ends, a button appears that lets the user move on to the first practice problem.

The Hands on Equation method appears to revolve around making both sides of the balance scale have the same value, using dice to represent known numbers and chess pieces to represent unknowns. The idea is that each chess piece stands for a number (solve for "x") and the student has to figure out what number the piece represents that would balance the scale. Every single problem in every lesson uses the exact same setup, with just the values of the dice and number of chess pieces (the ?equation?) varying.

The app is really fiddly to work with. In order to select a number as the answer, the student has to select the value off a spinning wheel. There is a button, "Auto Check," which plugs in the number the student assigned to show whether the equation balances. However, the problem is not complete until the student manually completes the "Check" equation by using the wheel to assign the value of both sides of the scale. The method for selecting the number was not touch-friendly, and the way the app handled "Auto Check" and "Check" was just pointless.

The ten additional exercises offer more room to practice, but I couldn't figure out why the app bothered to differentiate between them. It?s not as if the two ?practice problems? offered more assistance or tips than the ten ?exercises.? It was just more of the same in a separate section.

A Way to Learn Algebra
I don't expect all education programs to be entertaining, but it seems that if you are going to develop for a platform like the iPad, then you should try to make the learning process fun?or at least interactive. From the information available on the app it appears the Hands on Equations method is used in a classroom-based face-to-face setting. While it may work in a classroom, it falls flat on the iPad, and I was left wishing for something more like We Want to Know's DragonBox app. Something that focused on interactivity and fun while actually teaching algebra.

Hands on Equations for the iPad promises to demystify algebra, and it accomplishes that goal just fine, but it railroads the students through the lessons. Since there is precious little interactivity, there's no reason for Hands on Equations to be a mobile app. The same thing could more or less be accomplished with a YouTube video and a simple website.

More iPad App Reviews:

??? Hands on Equations (for iPad)
??? Grantophone (for iPhone and iPad)
??? Silversword (for iPad)
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?? more

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/WB5tjPURCT8/0,2817,2411275,00.asp

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25% of Americans Were Victims of Security Breaches in Past Year

One in four consumers in the United States had personal identification lost or stolen due to a data breach in the past year, a new study suggests.

[More from Mashable: Samsung Galaxy Phones May Be Vulnerable to Malicious Wiping]

Twenty-five percent of Americans have received a notification by a business, online service provider or organization that personal information such as passwords or credit card numbers were subject to a data breach, according to the study conducted by National Cyber Security Alliance and security firm McAfee for National Cyber Security Awareness month.

The news comes as various companies from LinkedIn, eHarmony, Internet radio platform Last.fm and Dropbox have had data compromised in recent months.

[More from Mashable: The 20 Worst PINs: Is Your ATM Code This Easy to Crack?]

SEE ALSO: PNC Is Latest Bank Hit With Major Cyberattack

With this in mind, about 90% of Americans said they do not feel completely safe from hackers, viruses and malware on the Internet. Consumers feel far more secure on smartphones -- in fact, about 63% said they believe their mobile devices are protected against hackers. But since 57% said they never back up their devices by storing information or data elsewhere and 63% don't use security software or apps to protect against viruses or malware, there is a disconnect on feeling secure and being secure, McAfee said.

"Similar to keeping ourselves healthy, Americans are aware that they need safe and secure Internet-connected devices, but they aren?t keeping up with the required actions to stay safe online," the company said on its blog.

Image courtesy of iStockphoto, Henrik5000

This story originally published on Mashable here.

Source: http://news.yahoo.com/25-americans-were-victims-security-breaches-past-114614713.html

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Hours of preparation for Romney ahead of debate

FILE - In this Sept. 9, 2012 file photo, Republican presidential candidate Mitt Romney arrives at his campaign headquarters in Boston, to prepare for the presidential debates. If Republican Mitt Romney doesn't perform well at the presidential debate on Wednesday, it's not for lack of trying. On one out of every four days this September, the Republican presidential nominee held preparation sessions for the first of his three debates with Democratic President Barack Obama. (AP Photo/Charles Dharapak)

FILE - In this Sept. 9, 2012 file photo, Republican presidential candidate Mitt Romney arrives at his campaign headquarters in Boston, to prepare for the presidential debates. If Republican Mitt Romney doesn't perform well at the presidential debate on Wednesday, it's not for lack of trying. On one out of every four days this September, the Republican presidential nominee held preparation sessions for the first of his three debates with Democratic President Barack Obama. (AP Photo/Charles Dharapak)

DENVER, Colo. (AP) ? If Republican Mitt Romney stumbles during Wednesday's presidential debate, it won't be for a lack of preparation.

The Republican presidential nominee has spent at least eight days over the past month getting ready for the three debates against President Barack Obama. He's holed up for hours on end with briefing books, top aides and his sparring partner, Ohio Republican Sen. Rob Portman, often at the expense of campaigning.

Romney began intense sessions Sept. 4 at an adviser's home in Vermont. Those ran for three days and drew the campaign's entire top echelon to a remote resort in the mountains. A few weeks later, top aides flew to Los Angeles for more practice. Romney has held debate practice at his Boston headquarters, and he spent part of last weekend at the Back Bay Events Center, where the auditorium holds 1,100 people.

The reasons are clear: The stakes are enormous given that Romney trails the president in surveys in key states and national polls favor Obama in a close race, and the debates are one of the Republican's final opportunities to shift the dynamics of the race. Millions of people are likely to watch the debate at the University of Denver, as well as two more slated later this month in New York and Florida. And Romney is looking to use the forums to put Obama on his heels in the homestretch.

As Romney has prepared for the first matchup, one question has loomed over the others among both advisers and observers: Will he provoke Obama or will Obama provoke him?

To varying degrees, each candidate has the same objective: to keep from looking defensive when he feels he's being unfairly or inaccurately criticized, while trying to get under his opponent's skin.

"The challenge that I'll have in the debate is that the president tends to, how shall I say it, to say things that aren't true," Romney told ABC News recently. "I've looked at prior debates. And in that kind of case, it's difficult to say, 'Well, am I going to spend my time correcting things that aren't quite accurate? Or am I going to spend my time talking about the things I want to talk about?'"

To guard against his trouble spot, Romney's sparring partner ? Portman ? has spent hours carefully weaving personal jibes into his answers during mock debate sessions in which longtime Romney adviser Peter Flaherty stood in for moderator Jim Lehrer. During each session, a group of top advisers ? including campaign manager Matt Rhoades, longtime aides Beth Myers and Eric Fehrnstrom and top strategist Stuart Stevens ? have dissected his answers and his body language ? and looked for ways to make him stronger.

Both campaigns have been working to lower expectations.

Romney's team has argued that Obama is a gifted speaker who has participated in general election presidential debates before, while Romney will engage in his first presidential fall matchup. Romney aides overlook the fact that he has a wealth of other debating experience, given that he participated in 19 primary debates during 2011 and 2012 ? more than 30 hours of time onstage with as many as 7 other candidates at a time ? and roughly the same number during the 2008 GOP primary race.

Romney typically emerged from those debates, usually 90 minutes with multiple opponents, as the clear leader. His performance in Jacksonville, Fla., helped seal his primary win there over former House Speaker Newt Gingrich ? though Gingrich had challenged him in an earlier debate in Tampa.

Romney rarely, however, has gone one-on-one against a political opponent, a format that leaves little time for contemplation in between answers to questions.

He did square off against a single rival in 1994 when he ran against Sen. Edward M. Kennedy. Those performances seemed to help the Democrat, who at one point offered this memorable line: "My opponent is multiple choice." It was a reference to Romney shifting his position on various issues. Democrats played the clip at the Democratic National Convention this year.

As part of his preparation, Romney has spent time watching video of Obama debating Democratic primary rival Hillary Rodham Clinton in 2008, including his cool retort to his opponent: "You're likable enough, Hillary." Romney advisers say the exchange shows Obama's occasional tendency to come across as imperious or removed from everyday concerns when he's questioned or criticized.

Romney's danger zone: getting hot when challenged.

That happened during a primary debate in Las Vegas, when Texas Gov. Rick Perry accused him of hiring illegal immigrants.

"Rick," Romney interjected, before Perry began talking over him again, and Romney repeatedly interrupted.

"I'm speaking. I'm speaking. I'm speaking. I'm speaking," Romney said, visibly agitated, at one point reaching over to put his hand on Perry's shoulder and trying to get CNN moderator Anderson Cooper to help. "You get 30 seconds. This is the way ? the way the rules work here is that I get 60 seconds, and then you get 30 seconds to respond, right? Anderson?"

Added Romney: "Would you please ? would you please wait? Are you just going to keep talking? Or are you going to let me finish with my ? what I had to say?"

Perry got to him again in another later debate where he challenged Romney on health care, with Romney playing into stereotypes of being wealthy and out of touch.

"Rick, I'll tell you what, 10,000 bucks?" Romney said. "$10,000 bet?"

It was a mistake, a rarity for a candidate who otherwise turned in solid performances and who is looking to do so again Wednesday.

__

Associated Press writer Steve Peoples contributed to this report.

__

Follow Kasie Hunt on Twitter at http://www.twitter.com/kasie

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-10-01-Romney-Debate%20Preview/id-705ed0807f6c462a9ed72782f02135be

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Iran unblocks Google email again after officials complain

DUBAI (Reuters) - Iranian authorities have reopened access to Google Inc's email service a week after blocking it, a government official and Iranians said on Monday.

Iran maintains one of the world's largest Internet filters, blocking access to tens of thousands of websites on the grounds that they are criminal or immoral, but the block on Gmail had even prompted complaints in parliament.

"The council on Internet filtering communicated its order to the Telecommunications Ministry regarding the lifting of the ban on the Gmail service," Mohammad Reza Aghamiri, a member of the committee, told the Mehr news agency.

Iranians contacted online said they had been able to access Gmail again since Sunday night.

An official had announced on September 23 that Gmail would be blocked throughout Iran "until further notice", without giving further details.

Iranian news agencies said the ban was connected to an anti-Islam film posted on Google's video hosting site YouTube that caused outrage throughout the Muslim world.

Iran has long blocked YouTube, but users appeared to have been getting around the block. Many Iranians circumvent Internet restrictions with "virtual private network" (VPN) software that makes their computer appear to be located in another country.

Despite the official announcement warning Iranians that Gmail would be blocked, Aghamiri had said last week that it had been an unintended consequence of an attempt to reinforce the block on YouTube.

"We wanted to ban YouTube and then Gmail was cut off as well, and this was unintended," he told Mehr.

"We absolutely do not want YouTube to be accessible. Therefore the telecommunications ministry is trying to find a way to solve this problem so that it can block YouTube in the HTTPS protocol while leaving Gmail accessible."

Intentional or not, the blocking of Gmail had prompted official complaints. One legislator, Hossein Garousi, threatened to summon Telecommunications Minister Reza Taqipour to parliament for questioning if it was not unblocked.

Many of the Internet restrictions date back to the use of sites such as Facebook and YouTube to rally and publicize mass anti-government protests after the disputed re-election of President Mahmoud Ahmadinejad in 2009.

Sites expressing anti-government views are routinely blocked.

In a report last month, the U.S.-based pro-democracy campaign group Freedom House said Iranian authorities were using "more nuanced tactics in a continued campaign against internet freedom" including "upgrading content filtering technology" and imposing harsh sentences for illegal online activities.

(Reporting by Yeganeh Torbati; Editing by Kevin Liffey)

Source: http://news.yahoo.com/iran-unblocks-google-email-again-officials-complain-113812931--sector.html

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